The COVID-19 pandemic has lately been driven by Omicron.

Torres, Carolina; Nabaes Jodar, Mercedes; Acuña, Dolores; Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Amadio, Ariel; Aulicino, Paula; Ceballos, Santiago; Cacciabue, Marco Polo Domingo; Debat, Humberto Julio; Dus Santos, Maria Jose; Eberhardt, María Florencia; Espul, Carlos; Fay, Fabián; Fernández, María Ailén; Fernandez, Franco Daniel; Fernandez Muñoz, Juan Manuel; Ferrini, Florencia; Gallego, Fernando; Giri, Adriana Angélica; Cerri, Agustina; Bolatti, Elisa; Gismondi, Maria Ines; Goya, Stephanie; Gramundi, Iván; Irazoqui, Jose Matias; Konig, Guido Alberto; Leiva, Viviana; Lucero, Horacio; Marquez, Nathalie; Nardi, Cristina; Ortiz, Belén; Pianciola, Luis; Pintos, Carolina Beatriz; Puebla, Andrea Fabiana; Rastellini, Carolina Victoria; Rojas, Alejandro Ezequiel; Sfalcin, Javier; Suárez, Ariel; Tittarelli, Estefanía; Toro, Rosana; Villanova, Gabriela Vanina; Ziehm, María Cecilia; Zimmermann, María Carla; Zunino, Sebastián; Proyecto PAIS Working Group; Valinotto, Laura; Viegas, Mariana

This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed. A differential dynamic between the Omicron waves was found. The third wave was associated with lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times of 3.3 days and a low level of lineage diversity and clustering.

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